REGENAPEP’s unique active ingredient, colostrum, is enriched with interleukin-1 receptor antagonist peptides (IL1RA) using a patent-pending production technology. IL1RA peptide, a natural amino acid complex, is a key blocker of the pro-inflammatory cytokine interleukin-1 (IL-1).
A significant body of research implicates IL-1 in the pathogenesis of arthritis. In both rheumatoid arthritis and osteoarthritis, IL-1 drives harmful musculoskeletal inflammation, leading to tissue destruction by inhibiting cell material synthesis and increasing the production of proteinase that are damaging to the overall joint structure. The effective inhibition of IL-1 using colostrum enriched with IL1RA peptides may significantly suppress inflammation and effectuate a cascade of ensuing benefits: pain reduction, prevention of disease deterioration and creation of better regenerative conditions for self-repair.
The botanical ingredients in REGENAPEP are demonstrated through clinical studies to cause anti-rheumatic and anti-inflammatory effects. They collectively block several inflammatory pathways by influencing cytokines that are key to causing inflammation.
Curcuma Longa reduces NF-κB, matrix metalloproteinases (MMPs) and prostaglandin E2; Salix Alba reduces IL-6 and TNF–α production; Harpagophytum Procumbens suppresses NF-κB and matrix metalloproteinases (MMPs); Boswellia Serrata decreases polymorphonuclear leukocyte infiltration and migration, and inhibits 5-lipoxygenase; Zingiber Officinale suppresses production of prostaglandin E2 and nitric oxide.
Inflammation is the primary cause of pain as tissue swelling adds pressure onto sensitive nerve endings at the inflamed area. The ingredients in REGENAPEP interact synergistically to relief pain by rapidly suppressing the underlying musculoskeletal and joint inflammation.
REGENAPEP’s IL1RA peptide (formulated as natural colostrum derivatives) and purified botanical ingredients not only relieve pain but also engender chondroprotective qualities. The ingredients may delay and reduce inflammatory degradation of articular cartilage, ultimately slowing down the deterioration of inflammatory-linked musculoskeletal and joint diseases, which may otherwise lead to expensive, highly invasive and risky surgical procedures (arthroplasty).
Harpagophytum Procumbens, a botanical ingredient in REGENAPEP, has a role in reducing cartilage degradation through the inhibition of matrix metalloproteinase (MMPs) and elastase.
IL1RA peptides (enriched in REGENAPEP’s colostrum) suppress specific IL-1 pro-inflammatory cytokines to impede the progression of arthritic disease, provide secondary pain reduction effect and allow for better regenerative conditions to the cartilage and synovium.
Curcuma longa, a botanical ingredient in REGENAPEP, can potently induce heme oxygenase-1 (HO-1) expression, which ultimately promotes mesenchymal stem cell osteoblast differentiation and inhibits adipocyte differentiation.
Recent studies demonstrated that white willow extract could also stimulate new cartilage formation by exerting anabolic effects on articular chondrocyte in animal models.
Curcumin Longa, a botanical ingredient in REGENAPEP, is capable of causing natural and lasting anti-depressant effect by increasing brain derived neurotrophic factor (BDNF) in hippocampus, which may assist in targeting depression symptomatically associated with arthritis.